MUSK Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
Aliasesmuscle, skeletal, receptor tyrosine kinase
ProductOrderM
Clone#10A4
Entrez GenelD4593
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.
MW97kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
IHC_P(Immunohistochemistry)1/200 - 1/1000
Sequence
Extra(24-209)
Catalog#: 20347
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Images
Immunohistochemical analysis
Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), muscles (B) and breast cancer (C) using MUSK mouse mAb with DAB staining.
Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), muscles (B) and breast cancer (C) using MUSK mouse mAb with DAB staining.
Immunofluorescence analysis
Figure 2: Confocal Immunofluorescence analysis of HEK293 cells trasfected with extracellular MUSK (aa24-209)-hIgGFc using MUSK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure 2: Confocal Immunofluorescence analysis of HEK293 cells trasfected with extracellular MUSK (aa24-209)-hIgGFc using MUSK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Product Overview
Description

MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

References (references)
References (references)1. J Neuroimmunol. 2006 Aug;177(1-2):119-31.
2. Ann N Y Acad Sci. 2008;1132:76-83.