MSH6 Primary Antibody

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Description

Defects in MSH6 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world. MSH6 is central to mismatch DNA repair.

Product Overview
Entrez GenelD
2956
Aliases
GTBP; HSAP; HNPCC5
Clone#
3A10H7
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of MSH6 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Oncology (Williston Park). 2005 Apr;19(4):455-63.
2. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):558-63.
Product Image
Western Blot
Figure 1: Western blot analysis using MSH6 mouse mAb against truncated MSH6 recombinant protein.
Figure 1: Western blot analysis using MSH6 mouse mAb against truncated MSH6 recombinant protein.
For Research Use Only. Not for use in diagnostic procedures.