MCP-1 Primary Antibody

Item Information

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Price

Description

Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.

Product Overview

Entrez GenelD

6347

Aliases

MCP1

Clone#

1A7B8

Host / Isotype

Mouse / IgG1 kappa

Immunogen

Purified recombinant fragment of human MCP-1 expressed in E. Coli.

Formulation

Ascitic fluid containing 0.03% sodium azide.

Storage

4°C; -20°C for long term storage

Product Applications

WB (Western Blot)

1/500 - 1/2000

ELISA

1/10000

References

1. Yoshimura T. et al. 1989. FEBS Lett. 244:487-493.
2. Yoshimura T. et al. 1991. Adv. Exp. Med. Biol. 305:47-56.
3. Rollins B.J. et al. 1991. Genomics. 10:489-492.

Product Image

Western Blot