MAPK8 Primary Antibody
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
2. Cell Cycle. 2010 May 15;9(10):1951-9.
![Figure 1: Western blot analysis using MAPK8 mAb against human MAPK8 (AA: 227-380) recombinant protein. (Expected MW is 43.4 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30369rwb.jpg?v=1666699945)
![Figure 2: Western blot analysis using MAPK8 mouse mAb against A431 (1), K562 (2), HeLa (3), NIH3T3 (4), PC-12 (5), and MCF-7 (6) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30369lwb.jpg?v=1666699945)
![Figure 3: Flow cytometric analysis of HeLa cells using MAPK8 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30369fcm.jpg?v=1666699945)
![Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30369ea.jpg?v=1666699945)