MAP3K7 Primary Antibody
|Aliases||TAK1; MEKK7; TGF1a|
|Formulation||Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer|
|Immunogen||Purified recombinant fragment of human MAP3K7 (AA: 471-579) expressed in E. Coli.|
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1:Western blot analysis using MAP3K7 mAb against human MAP3K7 (AA: 471-579) recombinant protein. (Expected MW is 45.1 kDa)
Figure 2:Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Figure 3:Western blot analysis using MAP3K7 mAb against HEK293 (1) and MAP3K7 (AA: 471-579)-hIgGFc transfected HEK293 (2) cell lysate.
|Description||The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.|
|References (references)||Asian Pac J Cancer Prev. 2013;14(1):315-20. |
Blood. 2012 Jul 12;120(2):347-55.