MAP3K7 Primary Antibody
Item Information
Catalog #
Size
Price
Description
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Product Overview
Entrez GenelD
6885
Aliases
TAK1; MEKK7; TGF1a
Clone#
3E8H4
Host / Isotype
Mouse / IgG2a
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human MAP3K7 (AA: 471-579) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
Asian Pac J Cancer Prev. 2013;14(1):315-20.
Blood. 2012 Jul 12;120(2):347-55.
Blood. 2012 Jul 12;120(2):347-55.
Product Image
Western Blot
Figure 1:Western blot analysis using MAP3K7 mAb against human MAP3K7 (AA: 471-579) recombinant protein. (Expected MW is 45.1 kDa)
Elisa
Figure 2:Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Western Blot
Figure 3:Western blot analysis using MAP3K7 mAb against HEK293 (1) and MAP3K7 (AA: 471-579)-hIgGFc transfected HEK293 (2) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.