MAP2K4 Primary Antibody

Item Information
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Description
MAP2K4(mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases.
MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.
Product Overview
Entrez GenelD
6416
Aliases
MAP2K4
Clone#
2D10D8
Host / Isotype
Mouse / IgM
Species Reactivity
Human
Immunogen
Purified recombinant fragment of MAP2K4 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Crews, C.M, et al. 1992. Science. 258: 478-480.
2. Cuenda A. 2000. Int. J. Biochem. Cell Biol, 32: 581-587.
3. Kim H. L, Vander Griend D. J, Yang X, et al. 2001.Cancer Res. 61: 2833-2837.
Product Image
Immunohistochemical analysis
Figure 1: Immunohistochemical analysis of paraffin-embedded human thymoma tissue (left) and spleen tissue (right), showing cytoplasmic localization using MAP2K4 mouse mAb with DAB staining.
Figure 1: Immunohistochemical analysis of paraffin-embedded human thymoma tissue (left) and spleen tissue (right), showing cytoplasmic localization using MAP2K4 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.