LRP1 Primary Antibody

Item Information

Catalog #

Size

Price

Description

The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.

Product Overview

Entrez GenelD

4035

Aliases

APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R

Clone#

1F6C6

Host / Isotype

Mouse / IgG1

Species Reactivity

Human

Immunogen

Purified recombinant fragment of human LRP1 (AA: 20-155) expressed in E. Coli.

Formulation

Purified antibody in PBS with 0.05% sodium azide

Storage

4°C; -20°C for long term storage

Product Applications

WB (Western Blot)

1/500 - 1/2000

ICC (Immunocytochemistry)

1/200 - 1/1000

FCM (Flow Cytometry)

1/200 - 1/400

ELISA

1/10000

References

1.Biomed Res Int. 2013;2013:152163.
2.J Transl Med. 2012 Aug 8;10:160.

Product Image

Elisa

Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);

Western Blot

Figure 2:Western blot analysis using LRP1 mAb against human LRP1 (AA: 20-155) recombinant protein. (Expected MW is 40.8 kDa)

Western Blot

Figure 3:Western blot analysis using LRP1 mAb against HEK293 (1) and LRP1 (AA: 20-155)-hIgGFc transfected HEK293 (2) cell lysate.

Immunofluorescence analysis

Figure 4:Immunofluorescence analysis of HeLa cells using LRP1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric