LPP Primary Antibody
LIM domain containing preferred translocation partner in lipoma. The Zyxin family of proteins contains five members, Ajuba, LIMD1, LPP,TRIP6 and Zyxin. LPP (LIM-containing lipoma-preferred partner), a LIM domain-containing scaffolding protein contains three LIM domains at its carboxy terminus, which are preceded by a proline-rich pre-LIM region containing a number of protein interaction domains. LPP, an 80 kDa protein, localizes to sites of cell adhesion, such as focal adhesions and cell-cell contacts,and shuttles to the nucleus where it has transcriptional activation capacity.The human LPP gene maps to chromosomal location 3q28, and preferentially translocates to the HMGIC gene in a subclass of human benign mesenchymal tumors known as lipomas.
2. Mol Cell Proteomics. 2005 Sep;4(9):1240-50. Epub 2005 Jun 11.
3. Cancer Genet Cytogenet. 2005 Nov;163(1):68-70.
![Figure 1: Western blot analysis using LPP mouse mAb against Hela (1), NIH/3T3 (2), COS (3), Caki (4), MCF-7 (5), HepG2 (6) and SMMC-7721 (7) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20178lwb.jpg?v=1666698573)
![Figure 2: Immunohistochemical analysis of paraffin-embedded human small intestine using LPP mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20178ihc-2.jpg?v=1666698573)
![Figure 3: Immunohistochemical analysis of paraffin-embedded human vessels tissues using LPP mouse mAb.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20178ihc-1.jpg?v=1666698573)
![Figure 4: Confocal Immunofluorescence analysis of COS cells using LPP mouse mAb (green). Red: Actin filaments have been labeled using DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20178icc-1.jpg?v=1666698573)
![Figure 5: Confocal Immunofluorescence analysis of Hela cells using LPP mouse mAb (green). Red: Actin filaments have been labeled using DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20178icc-2.jpg?v=1666698573)