LMNA Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesFPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1
ProductOrderL
Clone#4E7
Entrez GenelD4000
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human LMNA expressed in E. Coli.
MW74kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman, Mouse, Rat
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
212-477
Catalog#: 30247
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Images
Western Blot
Figure 1: Western blot analysis using LMNA mAb against human LMNA (AA: 212-477) recombinant protein. (Expected MW is 56.3 kDa)
Figure 1: Western blot analysis using LMNA mAb against human LMNA (AA: 212-477) recombinant protein. (Expected MW is 56.3 kDa)
Western Blot
Figure 2: Western blot analysis using LMNA mouse mAb against Raw264.7 (1), PC-12 (2), THP-1 (3), A431 (4), MCF-7 (5) and Jurkat (6) cell lysate.
Figure 2: Western blot analysis using LMNA mouse mAb against Raw264.7 (1), PC-12 (2), THP-1 (3), A431 (4), MCF-7 (5) and Jurkat (6) cell lysate.
Immunohistochemical analysis
Figure 3: Immunohistochemical analysis of paraffin-embedded human striated muscle tissues using LMNA mouse mAb with DAB staining.
Figure 3: Immunohistochemical analysis of paraffin-embedded human striated muscle tissues using LMNA mouse mAb with DAB staining.
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Product Overview
Description

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

References (references)
References (references)1. Muscle Nerve. 2010 Jan;41(1):85-91.
2. Endocrine. 2009 Dec;36(3):518-23.