LDLR Primary Antibody
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Biochim Biophys Acta. 2011 Jun;1811(6):397-408.
![Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30772ea_1.jpg?v=1666703532)
![Figure 2:Western blot analysis using LDLR mAb against human LDLR (AA: 22-150) recombinant protein. (Expected MW is 22-150 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30772rwb_1.jpg?v=1666703532)
![Figure 3:Western blot analysis using LDLR mAb against HEK293 (1) and LDLR(AA: 22-150)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30772twb_1.jpg?v=1666703532)
![Figure 4:Flow cytometric analysis of *** cells using *** mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30772fcm_1.jpg?v=1666703532)