KRT15 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesK15; CK15; K1CO; KRT1
ProductOrderK
Clone#6E7
Entrez GenelD3866
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2a
ImmunogenPurified recombinant fragment of KRT15 expressed in E. Coli.
MW49kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
IHC_P(Immunohistochemistry)1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
272-456
Catalog#: 20410
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Images
Western Blot
Figure 1: Western blot analysis using KRT15 mouse mAb against A431 cell lysate.
Figure 1: Western blot analysis using KRT15 mouse mAb against A431 cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using KRT15 mouse mAb
Figure 2: Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using KRT15 mouse mAb
Immunofluorescence analysis
Figure 3: Immunofluorescence analysis of HepG2(left) and PACN-1 (right) cells using KRT15 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Figure 3: Immunofluorescence analysis of HepG2(left) and PACN-1 (right) cells using KRT15 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Flow cytometric
Figure 4: Flow cytometric analysis of PACN-1 cells using KRT15 mouse mAb (green) and negative control (purple).
Figure 4: Flow cytometric analysis of PACN-1 cells using KRT15 mouse mAb (green) and negative control (purple).
Product Overview
Description

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 15 is a type I keratin without a defined type II partner. Keratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. Expression of keratin 15 is downregulated in some hyperproliferating situations, such as psoriasis and hypertrophic scars. Because keratinocytes in psoriasis and hypertrophic scars are activated, it is suggested that keratin 15 expression is not compatible with keratinocyte activation and the keratin 15 gene is downregulated to maintain the activated phenotype.

References (references)
References (references)1. J Invest Dermatol. 1999. 112(3):362-9
2. Exp Cell Res. 2006. 254(1):80-90
3. Mol Cell Biol. 2000. 24(8):3168-79