KLK3 Primary Antibody

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Description

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.

Product Overview
Entrez GenelD
354
Aliases
APS; PSA; hK3; KLK2A1
Clone#
8A12
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human KLK3 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
1. Oncogene. 2010 Jan 14;29(2):188-200.
2. Biol Chem. 2009 Sep;390(9):921-9.
Product Image
Western Blot
Figure 1: Western blot analysis using KLK3 mAb against human KLK3 (AA: 109-216) recombinant protein. (Expected MW is 37.2 kDa)
Figure 1: Western blot analysis using KLK3 mAb against human KLK3 (AA: 109-216) recombinant protein. (Expected MW is 37.2 kDa)
Flow cytometric
Figure 2: Flow cytometric analysis of HeLa cells using KLK3 mouse mAb (green) and negative control (red).
Figure 2: Flow cytometric analysis of HeLa cells using KLK3 mouse mAb (green) and negative control (red).
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
For Research Use Only. Not for use in diagnostic procedures.