Mouse Monoclonal Antibody to KLK2

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliaseshK2; hGK-1; KLK2A2
Clone#1C4H4
Entrez GenelD3817
FormulationPurified antibody in PBS with 0.05% sodium azide
ImmunogenPurified recombinant fragment of human KLK2 (AA: 25-261) expressed in E. Coli.
MW28.6kDa
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
25-261
Catalog#: 32257
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Images
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using KLK2 mAb against human KLK2 (AA: 25-261) recombinant protein. (Expected MW is 29 kDa)
Figure 2:Western blot analysis using KLK2 mAb against human KLK2 (AA: 25-261) recombinant protein. (Expected MW is 29 kDa)
Western Blot
Figure 3:Western blot analysis using KLK2 mAb against HEK293-6e (1) and KLK2 (AA: 25-261)-hIgGFc transfected HEK293-6e (2) cell lysate.
Figure 3:Western blot analysis using KLK2 mAb against HEK293-6e (1) and KLK2 (AA: 25-261)-hIgGFc transfected HEK293-6e (2) cell lysate.
Flow cytometric analysis
Figure 4:Flow cytometric analysis of K562 cells using KLK2 mouse mAb (green) and negative control (red).
Figure 4:Flow cytometric analysis of K562 cells using KLK2 mouse mAb (green) and negative control (red).
Immunohistochemical analysis
Figure 5:Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using KLK2 mouse mAb with DAB staining.
Figure 5:Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using KLK2 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 6:Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using KLK2 mouse mAb with DAB staining.
Figure 6:Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using KLK2 mouse mAb with DAB staining.
Product Overview
Description

This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants.

References (references)
References (references)1.Prostate. 2020 Sep;80(13):1097-1107. 2.Genes Cells. 2015 Jun;20(6):512-20.