KLHL1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesMRP2; FLJ30047; KIAA1490; KLHL1
ProductOrderK
Clone#3A8
Entrez GenelD57626
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human KLHL1 expressed in E. Coli.
MW82kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
202-506
Catalog#: 30110
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Images
Western Blot
Figure 1: Western blot analysis using KLHL1 mAb against human KLHL1 (AA: 202-506) recombinant protein. (Expected MW is 60.2 kDa)
Figure 1: Western blot analysis using KLHL1 mAb against human KLHL1 (AA: 202-506) recombinant protein. (Expected MW is 60.2 kDa)
Immunofluorescence analysis
Figure 2: Immunofluorescence analysis of NIH/3T3 cells using KLHL1 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Figure 2: Immunofluorescence analysis of NIH/3T3 cells using KLHL1 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Product Overview
Description

The mammalian Kelch like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin organizing proteins. Based on the presence of anti sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved in this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.Tissue specificity: Highly expressed in brain.

References (references)
References (references)1. DNA Res. 2000 Apr 28;7(2):143-50.
2. Nat Genet. 2004 Jan;36(1):40-5.
3. Science. 2005 Mar 11;307(5715):1621-5.