Sign up for news & promotions:
KAT6B Primary Antibody
|Aliases||qkf; MORF; MOZ2; GTPTS; MYST4; ZC2HC6B; querkopf|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human KAT6B (AA: 1186-1318) expressed in E. Coli.|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using KAT6B mAb against human KAT6B (AA: 1186-1318) recombinant protein. (Expected MW is 41.3 kDa)
Figure 3:Western blot analysis using KAT6B mAb against HEK293 (1) and KAT6B (AA: 1186-1318)-hIgGFc transfected HEK293 (2) cell lysate.
The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
|References (references)||1.Cancer Res. 2015 Sep 15;75(18):3936-45.
2.Int J Clin Exp Pathol. 2013 Nov 15;6(12):2864-71.