ITGA5 Primary Antibody
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.
2. J Cell Biol. 1998. 143(7):2081-92
3. Mol Biol Cell. 2000. 11(9):3109-21
4. J Cell Biol. 2001. 152(1):65-73
5. J Biol Chem. 2002. 277(22):19800-5
![Figure 1: Western blot analysis using ITGA5 mouse mAb against ITGA5-hIgGFc transfected HEK293 cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20411twb.jpg?v=1666698856)
![Figure 2: Immunohistochemical analysis of paraffin-embedded human Placenta tissues using ITGA5 mouse mAb](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20411ihc.jpg?v=1666698856)
![Figure 3: Flow cytometric analysis of Hela cells using ITGA5 mouse mAb (green) and negative control (purple).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20411fcm.jpg?v=1666698856)