IKBKB Primary Antibody
IKBKB(Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.
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![Figure 1: Western blot analysis using IKBKB mouse mAb against truncated IKBKB recombinant protein (1).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20114rwb.jpg?v=1666698471)
![Figure 2: Immunohistochemical analysis of paraffin-embedded human colon carcinoma(A), breast carcinoma(B), kidney cell carcinoma(C), bladder carcinoma tumor(D), showing membrane and cytoplasmic localization using IKBKB mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20114ihc.jpg?v=1666698471)