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IKBKB Primary Antibody
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Immunogen||Purified recombinant fragment of IKBKB expressed in E. Coli.|
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|IHC_P (Immunohistochemistry)||1/200 - 1/1000|
Figure 1: Western blot analysis using IKBKB mouse mAb against truncated IKBKB recombinant protein (1).
Figure 2: Immunohistochemical analysis of paraffin-embedded human colon carcinoma(A), breast carcinoma(B), kidney cell carcinoma(C), bladder carcinoma tumor(D), showing membrane and cytoplasmic localization using IKBKB mouse mAb with DAB staining.
|Description||IKBKB(Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.|
|References (references)||1. Azoitei N,et al. Biochemistry. 2005.14;44(23): 8326-36.
2. Kumar KA,et al. Neurosci Lett. 2003.10;340(2): 139-42.
3. Peet GW,et al. J Biol Chem. 1999 Nov 12;274(46): 32655-61.