IKBKB Primary Antibody

Item Information
Catalog # Size/Concentration Price
20114 100μl $352.00
Product OrderI
Entrez GeneID3551
FormulationAscitic fluid containing 0.03% sodium azide.
ImmunogenPurified recombinant fragment of IKBKB expressed in E. Coli.
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C.  Learn More
Species ReactivityHuman
IHC_P (Immunohistochemistry) 1/200 - 1/1000

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Western Blot

Cell Culture Products
Figure 1: Western blot analysis using IKBKB mouse mAb against truncated IKBKB recombinant protein (1).

Immunohistochemical analysis

Cell Culture Products
Figure 2: Immunohistochemical analysis of paraffin-embedded human colon carcinoma(A), breast carcinoma(B), kidney cell carcinoma(C), bladder carcinoma tumor(D), showing membrane and cytoplasmic localization using IKBKB mouse mAb with DAB staining.
Product Overview
Description IKBKB(Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.
References (references)
References (references) 1. Azoitei N,et al. Biochemistry. 2005.14;44(23): 8326-36.
2. Kumar KA,et al. Neurosci Lett. 2003.10;340(2): 139-42.
3. Peet GW,et al. J Biol Chem. 1999 Nov 12;274(46): 32655-61.

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