IKBKB Primary Antibody
Item Information
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Description
IKBKB(Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.
Product Overview
Entrez GenelD
3551
Aliases
IKBKB
Clone#
10A2
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of IKBKB expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Azoitei N,et al. Biochemistry. 2005.14;44(23): 8326-36.
2. Kumar KA,et al. Neurosci Lett. 2003.10;340(2): 139-42.
3. Peet GW,et al. J Biol Chem. 1999 Nov 12;274(46): 32655-61.
2. Kumar KA,et al. Neurosci Lett. 2003.10;340(2): 139-42.
3. Peet GW,et al. J Biol Chem. 1999 Nov 12;274(46): 32655-61.
Product Image
Western Blot
Figure 1: Western blot analysis using IKBKB mouse mAb against truncated IKBKB recombinant protein (1) and K562 cell lysate (2).
For Research Use Only. Not for use in diagnostic procedures.