IGF2BP3 Primary Antibody

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Description

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism.Tissue specificity: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines .IMP-3 is a marker for carcinomas and high-grade dysplastic lesions of pancreatic ductal epithelium.

Product Overview
Entrez GenelD
10643
Aliases
CT98; IMP3; KOC1; IMP-3; VICKZ3; DKFZp686F1078; IGF2BP3
Clone#
8F11
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human IGF2BP3 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Clin Cancer Res. 2008 Mar 15;14(6):1701-6.
2. Hepatology. 2008 Oct;48(4):1118-27.
Product Image
Western Blot
Figure 1: Western blot analysis using IGF2BP3 mouse mAb against Jurkat (1), K562 (2) and NTERA-2 (3) cell lysate.
Figure 1: Western blot analysis using IGF2BP3 mouse mAb against Jurkat (1), K562 (2) and NTERA-2 (3) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer (left) and colon tumour tissues (right) using IGC2BP3 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer (left) and colon tumour tissues (right) using IGC2BP3 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.