IGF2BP3 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesCT98; IMP3; KOC1; IMP-3; VICKZ3; DKFZp686F1078; IGF2BP3
ProductOrderI
Clone#8F11
Entrez GenelD10643
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human IGF2BP3 expressed in E. Coli.
MW69kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
127-358
Catalog#: 30129
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Images
Western Blot
Figure 1: Western blot analysis using IGF2BP3 mouse mAb against Jurkat (1), K562 (2) and NTERA-2 (3) cell lysate.
Figure 1: Western blot analysis using IGF2BP3 mouse mAb against Jurkat (1), K562 (2) and NTERA-2 (3) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer (left) and colon tumour tissues (right) using IGC2BP3 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer (left) and colon tumour tissues (right) using IGC2BP3 mouse mAb with DAB staining.
Product Overview
Description

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism.Tissue specificity: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines .IMP-3 is a marker for carcinomas and high-grade dysplastic lesions of pancreatic ductal epithelium.

References (references)
References (references)1. Clin Cancer Res. 2008 Mar 15;14(6):1701-6.
2. Hepatology. 2008 Oct;48(4):1118-27.