IFN-gamma Primary Antibody
Item Information
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Description
Interferon-? (IFN-?) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-? strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB
Product Overview
Entrez GenelD
3458
Aliases
IFG; IFI
Clone#
3F1E3
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human IFN-γ expressed in E. Coli.
Formulation
Purified antibody in PBS containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Takayanagi, H. et al. Nature 2000. 408: 600-605.
2. Tsubota, K. et al. Invest. Ophthal. Vis. Sci. 40: 28-34, 1999.
2. Tsubota, K. et al. Invest. Ophthal. Vis. Sci. 40: 28-34, 1999.
Product Image
Western Blot
Figure 1: Western blot analysis using IFN gamma mouse mAb against truncated IFN-gamma recombinant protein.
For Research Use Only. Not for use in diagnostic procedures.