HLA-DPA1
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
2.HLA. 2022 Jan;99(1):74-75.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32424ea.jpg?v=1669029788)
![Figure 2:Western blot analysis using HLA-DPA1 mAb against human HLA-DPA1 (AA: 29-209) recombinant protein. (Expected MW is 23.7 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32424rwb.jpg?v=1669029788)
![Figure 3:Western blot analysis using HLA-DPA1 mAb against HEK293-6e (1) and HLA-DPA1 (AA:29-209)-hIgGFc transfected HEK293-6e (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32424twb.jpg?v=1669029788)
![Figure 4:Western blot analysis using HLA-DPA1 mouse mAb against Raji(1) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32424lwb.jpg?v=1669029788)
![Figure 5:Flow cytometric analysis of Jurkat cells using HLA-DPA1 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32424fcm.jpg?v=1669029788)
![Figure 6:Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using HLA-DPA1 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32424ihc.jpg?v=1669029788)
![Figure 7:Immunohistochemical analysis of paraffin-embedded breast cancer tissues using HLA-DPA1 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32424ihc-1.jpg?v=1669029789)
![Figure 8:Immunohistochemical analysis of paraffin-embedded gastric cancer tissues using HLA-DPA1 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32424ihc-2.jpg?v=1669029789)
![Figure 9:Immunohistochemical analysis of paraffin-embedded rectal cancer tissues using HLA-DPA1 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32424ihc-3.jpg?v=1669029789)