HDAC4 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesHD4; HDACA; HA6116; HDAC-A; KIAA0288; HDAC4
ProductOrderH
Clone#7B2
Entrez GenelD9759
FormulationPurified antibody in PBS containing 0.05% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human HDAC4 expressed in E. Coli.
MW119kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
N
Catalog#: 20423
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Images
Western Blot
Figure 1: Western blot analysis using HDAC4 mouse mAb against Hela (1), Jurkat (2) cell lysate.
Figure 1: Western blot analysis using HDAC4 mouse mAb against Hela (1), Jurkat (2) cell lysate.
Product Overview
Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

References (references)
References (references)1. Biochem Biophys Res Commun. 2008 Dec 19;377(3):852-6.
2. Curr Top Med Chem. 2009;9(3):235-40.
3. Nucleic Acids Res. 2010 May;38(9):2813-24.