HDAC3 Primary Antibody
HDAC3: histone deacetylase 3, also known as HD3, RPD3, RPD3-2. Entrez Protein NC_000005. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
2. Mol Cell Biol. 2007 Feb;27(4):1280-95.
3. Mol Carcinog. 2008 Feb;47(2):137-47.
![Figure 1: Western blot analysis using HDAC3 mouse mAb against truncated Trx-HDAC3 recombinant protein (1), full length HDAC3-hIgGFc (aa1-428) transfected CHO-K1 cell lysate(2) and Hela cell lysate (3).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20260twb.jpg?v=1666698665)
![Figure 2: Immunohistochemical analysis of paraffin-embedded human esophagus cancer (left) and breast carcinoma tissue (right), showing nuclear localization with DAB staining using HDAC3 mouse mAb.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20260ihc.jpg?v=1666698665)