GRIN2A Primary Antibody
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.
Purified recombinant fragment of human GRIN2A (AA: extra 23-165) expressed in E. Coli.
Purified antibody in PBS with 0.05% sodium azide
4°C; -20°C for long term storage
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using GRIN2A mAb against human GRIN2A (AA: extra 23-165) recombinant protein. (Expected MW is 41.3 kDa)
Figure 3:Western blot analysis using GRIN2A mAb against HEK293 (1) and GRIN2A (AA: extra 23-165)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Flow cytometric analysis of Hela cells using GRIN2A mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.