GRIN2A Primary Antibody
Item Information
Catalog #
Size
Price
Description
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.
Product Overview
Entrez GenelD
2903
Aliases
LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A
Clone#
3G10F9
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human GRIN2A (AA: extra 23-165) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
1.PLoS Genet. 2014 Nov 20;10(11):e1004788.
2.PLoS One. 2014 Jun 10;9(6):e99294.
2.PLoS One. 2014 Jun 10;9(6):e99294.
Product Image
Elisa
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using GRIN2A mAb against human GRIN2A (AA: extra 23-165) recombinant protein. (Expected MW is 41.3 kDa)
Western Blot
Figure 3:Western blot analysis using GRIN2A mAb against HEK293 (1) and GRIN2A (AA: extra 23-165)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 4:Flow cytometric analysis of Hela cells using GRIN2A mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.