GRIA3 Primary Antibody
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
2. Am J Med Genet A. 2009 Jun;149A(6):1280-9.
![Figure 1: Western blot analysis using GRIA3 mAb against HEK293 (1) and GRIA3(AA: 683-824)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30233twb.jpg?v=1666699435)
![Figure 2: Immunohistochemical analysis of paraffin-embedded human brain tissues (left) and rat brain tissues (right) using GRIA3 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30233ihc.jpg?v=1666699436)
![Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30233ea.jpg?v=1666699436)