GRIA3 Primary Antibody

Item Information

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Price

Description

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.

Product Overview

Entrez GenelD

2892

Aliases

GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3

Clone#

1D2

Host / Isotype

Mouse / IgG1

Species Reactivity

Human

Immunogen

Purified recombinant fragment of human GRIA3 expressed in E. Coli.

Formulation

Ascitic fluid containing 0.03% sodium azide.

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Product Applications

WB (Western Blot)

1/500 - 1/2000

IHC_P(Immunohistochemistry)

1/200 - 1/1000

ELISA

1/10000

References

1. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):468-76.
2. Am J Med Genet A. 2009 Jun;149A(6):1280-9.

Product Image

Western Blot

Figure 1: Western blot analysis using GRIA3 mAb against HEK293 (1) and GRIA3(AA: 683-824)-hIgGFc transfected HEK293 (2) cell lysate.

Immunohistochemical analysis

Figure 2: Immunohistochemical analysis of paraffin-embedded human brain tissues (left) and rat brain tissues (right) using GRIA3 mouse mAb with DAB staining.

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