FOXP2 Primary Antibody
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
Purified antibody in PBS with 0.05% sodium azide
4°C; -20°C for long term storage
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using FOXP2 mAb against human FOXP2 (AA: 641-740) recombinant protein. (Expected MW is 36.7 kDa)
Figure 3:Western blot analysis using FOXP2 mAb against HEK293 (1) and FOXP2 (AA: 641-740)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Western blot analysis using FOXP2 mouse mAb against HepG2 (1) cell lysate.
Figure 5:Flow cytometric analysis of HeLa cells using FOXP2 mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.