FOXD3 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesAIS1; HFH2; Genesis; FOXD3
ProductOrderF
Clone#5G9
Entrez GenelD27022
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human FOXD3 expressed in E. Coli.
MW48kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman, Mouse, Monkey
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
132-293
Catalog#: 30128
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Images
Western Blot
Figure 1: Western blot analysis using FOXD3 mouse mAb against NTERA-1 (1)?HUVE-12 (2), HEK293 (3), Hela (4), Jurkat (5), NIH/3T3 (6), K562 (7), RAW264.7 (8) and COS7 (9) cell lysate.
Figure 1: Western blot analysis using FOXD3 mouse mAb against NTERA-1 (1)?HUVE-12 (2), HEK293 (3), Hela (4), Jurkat (5), NIH/3T3 (6), K562 (7), RAW264.7 (8) and COS7 (9) cell lysate.
Product Overview
Description

FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation . FoxD3 is required for the maintenance of the mammalian neural crest; FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures . FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells .Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis .Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined .

References (references)
References (references)1. Blood. 1993 Jun 1;81(11):2854-9.
2. Am J Hum Genet. 2001 Mar;68(3):627-41.