FGG Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesFGG
ProductOrderF
Clone#5A6
Entrez GenelD2266
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2b
ImmunogenPurified recombinant fragment of human FGG expressed in E. Coli.
MW52kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
210-437
Catalog#: 30267
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Images
Western Blot
Figure 1: Western blot analysis using FGG mAb against human FGG (AA: 210-437) recombinant protein. (Expected MW is 51.5 kDa)
Figure 1: Western blot analysis using FGG mAb against human FGG (AA: 210-437) recombinant protein. (Expected MW is 51.5 kDa)
Immunofluorescence analysis
Figure 2: Immunofluorescence analysis of NIH/3T3 cells using FGG mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Figure 2: Immunofluorescence analysis of NIH/3T3 cells using FGG mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Product Overview
Description

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.

References (references)
References (references)1. Biochemistry. 2009 Sep 15;48(36):8656-63.
2. Blood. 2009 Nov 5;114(19):3994-4001.