FGFR1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesCEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; HBGFR
ProductOrderF
Clone#3D4F7
Entrez GenelD2260
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2b
ImmunogenPurified recombinant extracellular fragment of human FGFR1 (aa22-376) fused with hIgGFc tag expressed in HEK293 cells.
MW92kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
Extra(22-376)/68.8
Catalog#: 20359
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Images
Western Blot
Figure 1: Western blot analysis using FGFR1 mouse mAb against extracellular domain of human FGFR1 (aa22-376).
Figure 1: Western blot analysis using FGFR1 mouse mAb against extracellular domain of human FGFR1 (aa22-376).
Product Overview
Description

Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome. It is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.

References (references)
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