F8 Primary Antibody

Item Information
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Description

F8: coagulation factor VIII, procoagulant component. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Product Overview
Entrez GenelD
2157
Aliases
AHF; F8B; F8C; HEMA; FVIII
Clone#
5E9B2
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of F8 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Thromb Haemost. 2007 Nov;98(5):1031-9.
2. Blood. 2008 Apr 1;111(7):3468-78.
Product Image
Western Blot
Figure 1: Western blot analysis using F8 mouse mAb against truncated Trx-F8 recombinant protein (1).
Figure 1: Western blot analysis using F8 mouse mAb against truncated Trx-F8 recombinant protein (1).
For Research Use Only. Not for use in diagnostic procedures.