EphB4 Primary Antibody
EPH receptor B4 (EphB4), with 987-amino acid protein (about 108kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptor tyrosine kinases and their ligands, the ephrins, regulate numerous biological processes in developing and adult tissues and have been implicated in cancer progression and in pathological forms of angiogenesis. EphB4 acts as a negative regulator of blood vessel branching and vascular network formation, switching the vascularization program from sprouting angiogenesis to circumferential vessel growth. EphB4 and its ligand ephrinB2 express in several kinds of tumor cells and correlate with tumorigenesis. EphB4 is thus a potential candidate as a predictor of disease outcome in several kinds of tumor and as target for novel therapy.
2. Qinghua WU, Zhenhe SUO,Bjon RISBERG. Pathol Oncol Res. 2004;10(1):26-33.
![Figure 1: Western blot analysis using EphB4 mouse mAb against truncated EphB4 recombinant protein.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20073rwb.jpg?v=1666698416)
![Figure 2: Immunohistochemical analysis of paraffin-embedded Human pancreas carcinoma (left) and breast carcinoma (right) tissue, showing membrane and cytoplasmic (pancreas carcinoma) localization, membrane (breast carcinoma) localization using EphB4 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20073ihc.jpg?v=1666698416)