EphA2 Primary Antibody
Item Information
Catalog #
Size
Price
Description
EPH receptor A2 (EphA2), with 976-amino acid protein (about 107 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphA10, EphB1, EphB2, EphB3, EphB4 and EphB6 are Eph family receptors for Ephrin family ligands. In normal cells, EphA2 negatively regulates cell growth and invasiveness. EphA2 is overexpressed by many human cancers, and is often associated with poor prognostic features. The clinical significance of the expression of EphA2 was observed in breast, prostate, colon, skin, cervical, ovarian, and lung cancers.EphA2 may serve as a novel target for bladder cancer, colonic adenocarcinoma and ovarian cancer therapy.
Product Overview
Entrez GenelD
1969
Aliases
ECK; EPHA2
Clone#
1B3C7
Host / Isotype
Mouse / IgM
Species Reactivity
Human
Immunogen
Purified recombinant fragment of EphA2 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Shaji Abraham, Deborah W. Knapp, Liang Cheng. Clin Cancer Res. 2006 Jan 15;12(2):353-60.
2. Charles N Landen, Michael S Kinch, Anil K Sood. Expert Opin Ther Targets. 2005 Dec;9(6):1179-87.
2. Charles N Landen, Michael S Kinch, Anil K Sood. Expert Opin Ther Targets. 2005 Dec;9(6):1179-87.
Product Image
Western Blot
Figure 1: Western blot analysis using EphA2 mouse mAb against NIH/3T3 cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human skin carcinoma (left) and pancreas carcinoma (right) tissue, showing cytoplasmic localization using EphA2 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.