Cytokeratin 5 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesK5; CK5; KRT5A; KRT5
ProductOrderC
Clone#1E1
Entrez GenelD3852
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of Cytokeratin 5 expressed in E. Coli.
MW62.3kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
316-590
Catalog#: 20322
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Images
Western Blot
Figure 1: Western blot analysis using CK5 mouse mAb against Hela cell lysate (1).
Figure 1: Western blot analysis using CK5 mouse mAb against Hela cell lysate (1).
Product Overview
Description

Cytokeratin 5, also known as CK5, KRT5. It is a member of the keratin gene family. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin5 gene (KRT5) have been shown to result in the autosomal dominant disorderepidermolysis bullosa (EB). Defects in KRT5 are a cause of epidermolysis bullosa simplex.

References (references)
References (references)1. J Invest Dermatol. 2003 Sep;121(3):482-5.
2. J Cell Sci. 2005 Mar 1;118(Pt 5):1081-90.