CTTN Primary Antibody
|Aliases||EMS1; FLJ34459; CTTN|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Immunogen||Purified recombinant fragment of human CTTN expressed in E. Coli. |
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|Species Reactivity||Human, Mouse|
|IHC_P(Immunohistochemistry)||1/200 - 1/1000|
|WB (Western Blot)||1/500 - 1/2000|
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Figure 1: Western blot analysis using CTTN mouse mAb against Hela (1), A431 (2), MCF-7 (3), SR-BR-3 (4), HepG2 (5) and NIH/3T3 (6) cell lysate.
Figure 2: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues (left) and tonsil tissues (right) using CTTN mouse mAb with DAB staining.
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. (provided by RefSeq)
|References (references)||1. Ai Zheng. 2008 Mar;27(3):323-6. |
2. Dis Markers. 2008;25(1):17-26.