CTNNB1 Primary Antibody

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Description

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Product Overview
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4°C; -20°C for long term storage
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ELISA
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)
WESTERN BLOT
Figure 2: Western blot analysis using CTNNB1 mAb against human CTNNB1 (AA: 632-781) recombinant protein. (Expected MW is 36 kDa)
Figure 2: Western blot analysis using CTNNB1 mAb against human CTNNB1 (AA: 632-781) recombinant protein. (Expected MW is 36 kDa)
WESTERN BLOT
Figure 4: Western blot analysis using CTNNB1 mouse mAb against Hela (1), HepG2 (2),NIH3T3 (3),MCF-7 (4), C6 (5),COS-7 (6),K562 (7),Jurkat (8), A549 (9),SH-SY5Y (10),BEL-7402 (11), HEK293 (12), and HEK293-6e (13) cell lysate.
Figure 4: Western blot analysis using CTNNB1 mouse mAb against Hela (1), HepG2 (2),NIH3T3 (3),MCF-7 (4), C6 (5),COS-7 (6),K562 (7),Jurkat (8), A549 (9),SH-SY5Y (10),BEL-7402 (11), HEK293 (12), and HEK293-6e (13) cell lysate.
FLOW CYTOMETRY
Figure 5: Flow cytometric analysis of HepG2 cells using CTNNB1 mouse mAb (green) and negative control (red).
Figure 5: Flow cytometric analysis of HepG2 cells using CTNNB1 mouse mAb (green) and negative control (red).
FLOW CYTOMETRY
Figure 6: Flow cytometric analysis of A549 cells using CTNNB1 mouse mAb (green) and negative control (red).
Figure 6: Flow cytometric analysis of A549 cells using CTNNB1 mouse mAb (green) and negative control (red).
IMMUNOHISTOCHEMISTRY
Figure 7: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CTNNB1 mouse mAb with DAB staining.
Figure 7: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CTNNB1 mouse mAb with DAB staining.
IMMUNOHISTOCHEMISTRY
Figure 8: Immunohistochemical analysis of paraffin-embedded rectal cancer tissues using CTNNB1 mouse mAb with DAB staining.
Figure 8: Immunohistochemical analysis of paraffin-embedded rectal cancer tissues using CTNNB1 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.

Catalog#: 31971

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