CSNK2A2 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesCK2A2; CSNK2A1; FLJ43934
ProductOrderC
Clone#1E1
Entrez GenelD1459
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human CSNK2A2 (AA: 194-350) expressed in E. Coli.
MW41.2kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman, Mouse
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
194-350
Catalog#: 30405
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Images
Western Blot
Figure 1: Western blot analysis using CSNK2A2 mAb against human CSNK2A2 recombinant protein. (Expected MW is 44 kDa)
Figure 1: Western blot analysis using CSNK2A2 mAb against human CSNK2A2 recombinant protein. (Expected MW is 44 kDa)
Western Blot
Figure 2: Western blot analysis using CSNK2A2 mouse mAb against HeLa (1), MCF-7 (2), HepG2 (3), Jurkat (4), NIH3T3 (5), and PC-12 (6) cell lysate.
Figure 2: Western blot analysis using CSNK2A2 mouse mAb against HeLa (1), MCF-7 (2), HepG2 (3), Jurkat (4), NIH3T3 (5), and PC-12 (6) cell lysate.
Flow cytometric
Figure 3: Flow cytometric analysis of HepG2 cells using CSNK2A2 mouse mAb (green) and negative control (red).
Figure 3: Flow cytometric analysis of HepG2 cells using CSNK2A2 mouse mAb (green) and negative control (red).
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
Description

Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

References (references)
References (references)1.Eur J Immunol. 2009 Jan;39(1):267-79. 2.Cell Mol Life Sci. 2009 Jan;66(2):339-49.