CSF1R Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesFMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R
ProductOrderC
Clone#4C9G2
Entrez GenelD1436
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human CSF1R (AA: 20-152) expressed in E. Coli.
MW108kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
20-152
Catalog#: 30773
Inquire
Contact us to order
Images
Elisa
Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Western Blot
Figure 2:Western blot analysis using CSF1R mAb against human CSF1R (AA: 20-152) recombinant protein. (Expected MW is 27.2 kDa)
Figure 2:Western blot analysis using CSF1R mAb against human CSF1R (AA: 20-152) recombinant protein. (Expected MW is 27.2 kDa)
Western Blot
Figure 3:Western blot analysis using CSF1R mAb against HEK293 (1) and CSF1R (AA: 20-152)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 3:Western blot analysis using CSF1R mAb against HEK293 (1) and CSF1R (AA: 20-152)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 4:Flow cytometric analysis of Hela cells using CSF1R mouse mAb (green) and negative control (red).
Figure 4:Flow cytometric analysis of Hela cells using CSF1R mouse mAb (green) and negative control (red).
Product Overview
DescriptionThe protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
References (references)
References (references)PLoS One. 2011;6(11):e27450.
J Biochem. 2012 Jan;151(1):47-55.