CK17 Primary Antibody
CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
2. Br J Dermatol. 1995 Oct;133(4):501-11.
![Figure 1: Western blot analysis using CK17 mouse mAb against Hela (1), MCF-7 (2) and A431 (3) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20363lwb.jpg?v=1666698805)
![Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), endometrial carcinoma (B), sublingual gland (C) and esophagus (D) tissues using CK17 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20363ihc.jpg?v=1666698805)