CK17 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesPC; K17; PC2; PCHC1; KRT17
ProductOrderC
Clone#3B12
Entrez GenelD3872
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2b
ImmunogenPurified recombinant fragment of CK17 expressed in E. Coli.
MW49kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
306-430
Catalog#: 20363
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Images
Western Blot
Figure 1: Western blot analysis using CK17 mouse mAb against Hela (1), MCF-7 (2) and A431 (3) cell lysate.
Figure 1: Western blot analysis using CK17 mouse mAb against Hela (1), MCF-7 (2) and A431 (3) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), endometrial carcinoma (B), sublingual gland (C) and esophagus (D) tissues using CK17 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), endometrial carcinoma (B), sublingual gland (C) and esophagus (D) tissues using CK17 mouse mAb with DAB staining.
Product Overview
Description

CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.

References (references)
References (references)1. Am J Pathol. 2002 Dec;161(6):1991-6.
2. Br J Dermatol. 1995 Oct;133(4):501-11.