CIB1 Primary Antibody
Item Information
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Description
CIB1(also designated calcium and integrin binding 1 or calmyrin),with 191-amino acid protein(about 21kDa), belongs to the calcium-binding protein family.CIB1 is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining.CIB1 is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alpha(IIb)beta(3) integrin and several serine/threonine kinases and potentially modulates their function.CIB1 regulates platelet aggregation in hemostasis through a specific interaction with the alpha(IIb) cytoplasmic domain of platelet integrin alpha(IIb)beta(3). CIB1 is also ubiquitously expressed activating and inhibiting protein ligand of the InsP3R.
Product Overview
Entrez GenelD
10519
Aliases
CIB; KIP; KIP1; SIP2-28
Clone#
5A1F5E12
Species Reactivity
Human
Immunogen
Purified recombinant fragment of CIB1 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Holly R. Gentry,Alex U. Singer, Laurie Betts. J. Biol. Chem., Mar 2005; 280: 8407 - 8415.
2. Carl White, Jun Yang, Mervyn J. Monteiro. J. Biol. Chem., Jul 2006; 281: 20825 - 20833.
2. Carl White, Jun Yang, Mervyn J. Monteiro. J. Biol. Chem., Jul 2006; 281: 20825 - 20833.
Product Image
Western Blot
Figure 1: Western blot analysis using CIB1 mouse mAb against truncated CIB1 recombinant protein (1) and A431 cell lysate (2).
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human thalamus (left) and glioma (right) tissue, showing membrane localization using CIB1 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.