CEBPB Primary Antibody
|Aliases||LAP; CRP2; TCF5; IL6DBP; NF-IL6; MGC32080; C/EBP-beta|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Immunogen||Purified recombinant fragment of human CEBPB expressed in E. Coli.|
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
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Figure 1: Western blot analysis using CEBPB mAb against human CEBPB (AA: 161-338) recombinant protein. (Expected MW is 44.5 kDa)
Figure 2: Flow cytometric analysis of MCF-7 cells using CEBPB mouse mAb (blue) and negative control (red).
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. Tissue specificity: Expressed at low levels in the lung, kidney and spleen.
|References (references)||1. Biochem J. 2009 Dec 14;425(1):215-23. |
2. Cell Signal. 2009 Dec;21(12):1918-24.