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CD45 Primary Antibody
|Aliases||LCA; LY5; B220; CD45; T200; CD45R; GP180; PTPRC|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Immunogen||Purified recombinant fragment of CD45 expressed in E. Coli.\
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|IHC_P (Immunohistochemistry)||1/200 - 1/1000|
Figure 1: Western blot analysis using anti-CD45 monoclonal antibody against truncated CD45 recombinant protein (1).
Figure 2: Immunohistochemical analysis of paraffin-embedded human lymph node tissue,showing membrane and cytoplasmic localization with DAB staining using CD45 mouse mAb.
|Description||CD45, also known as TPRC(protein tyrosine phosphatase, receptor type, C). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.|
|References (references)||1. Biol Chem. 2008 May;389(5):561-8.
2. Immunology. 2008 Dec;125(4):558-69.