CD43 Primary Antibody
This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome.
2.Hum Pathol. 2015 Apr;46(4):593-9.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31582ea.jpg?v=1666704053)
![Figure 2:Western blot analysis using CD43 mAb against human CD43 (AA: extra 20-253) recombinant protein. (Expected MW is 49.4 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31582rwb.jpg?v=1666704053)
![Figure 3:Western blot analysis using CD43 mAb against HEK293 (1) and CD43 (AA: extra 20-253)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31582twb.jpg?v=1666704053)
![Figure 4:Flow cytometric analysis of HL-60 cells using CD43 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31582fcm.jpg?v=1666704053)