CD40 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
Aliasesp50; Bp50; CDW40; TNFRSF5
ProductOrderC
Clone#9G10
Entrez GenelD958
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of CD40 expressed in E. Coli.
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
Sequence
20-165(WY blast)
Catalog#: 20366
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Images
Immunofluorescence analysis
Figure 1: Confocal Immunofluorescence analysis of human peripheral blood lymphocyles (left) and mouse L1210 cells (right) using CD40 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure 1: Confocal Immunofluorescence analysis of human peripheral blood lymphocyles (left) and mouse L1210 cells (right) using CD40 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Product Overview
Description

CD40 molecule, TNF receptor superfamily member 5. It is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

References (references)
References (references)1. Clin Cancer Res. 2003 Feb;9(2):722-8.
2. Clin Cancer Res. 2003 Feb;9(2):619-24.
3. Immunity. 1999 Sep;11(3):339-48.