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CD360 Primary Antibody
|Aliases||IL21R; NILR; IMD56|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human CD360 (AA: extra 20-232) expressed in E. Coli.|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using CD360 mAb against human CD360 (AA: extra 20-232) recombinant protein. (Expected MW is 50.5 kDa)
Figure 3:Western blot analysis using CD360 mAb against HEK293 (1) and CD360 (AA: extra 20-232)-hIgGFc transfected HEK293 (2) cell lysate.
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
|References (references)||1.Vasc Med. 2016 Apr;21(2):99-104.
2.J Interferon Cytokine Res. 2015 Jan;35(1):42-8.