CD268 Primary Antibody
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
Purified antibody in PBS with 0.05% sodium azide
4°C; -20°C for long term storage
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using CD268 mAb against human CD268 (AA: extra 1-78) recombinant protein. (Expected MW is 34 kDa)
Figure 3:Western blot analysis using CD268 mAb against HEK293 (1) and CD268 (AA: extra 1-78)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Western blot analysis using CD268 mouse mAb against C6 (1) cell lysate.
Figure 5:Flow cytometric analysis of Raji cells using CD268 mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.