CD247 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesT3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA; CD247
ProductOrderC
Clone#4B10
Entrez GenelD919
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human CD247 expressed in E. Coli.
MW18kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
IHC_P(Immunohistochemistry)1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
52-164
Catalog#: 30017
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Images
Western Blot
Figure 1: Western blot analysis using CD247 mAb against CD247(AA: 52-164)-hIgGFc transfected HEK293 cell lysate.
Figure 1: Western blot analysis using CD247 mAb against CD247(AA: 52-164)-hIgGFc transfected HEK293 cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human Thymus tissues using anti-CD247 mouse mAb
Figure 2: Immunohistochemical analysis of paraffin-embedded human Thymus tissues using anti-CD247 mouse mAb
Immunofluorescence analysis
Figure3: Immunofluorescence analysis of K562 cells using anti-CD247 mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure3: Immunofluorescence analysis of K562 cells using anti-CD247 mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Flow cytometric
Figure 4: Flow cytometric analysis of Jurkat cells using anti-CD247 mAb (green) and negative control (purple).
Figure 4: Flow cytometric analysis of Jurkat cells using anti-CD247 mAb (green) and negative control (purple).
Product Overview
Description

The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

References (references)
References (references)1. J Immunol. 2002 Aug 15;169(4):1705-12.
2. Arthritis Rheum. 2003 Jul;48(7):1948-55.
3. Nat Methods. 2005 Aug;2(8):591-8.