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CD218A Primary Antibody
|Aliases||IL18R1; IL18RA; IL1RRP; CDw218a; IL-1Rrp|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human CD218A (AA: extra 22-185) expressed in E. Coli.|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using CD218A mAb against human CD218A (AA: extra 22-185) recombinant protein. (Expected MW is 45.2 kDa)
Figure 3:Western blot analysis using CD218A mAb against HEK293 (1) and CD218A (AA: extra 22-185)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Flow cytometric analysis of HL-60 cells using CD218A mouse mAb (green) and negative control (red).
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
|References (references)||1.PLoS One. 2014 Oct 31;9(10):e110734.
2.Mult Scler. 2010 Sep;16(9):1056-65.