CD217 Primary Antibody
Item Information
Catalog #
Size
Price
Description
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
Product Overview
Entrez GenelD
23765
Aliases
IL17RA; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R
Clone#
6H1B1
Host / Isotype
Mouse / IgG2b
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human CD217 (AA: extra 33-320) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
1.Oncotarget. 2016 Feb 2;7(5):6121-35.
2.Int J Clin Exp Pathol. 2015 Jun 1;8(6):7002-8.
2.Int J Clin Exp Pathol. 2015 Jun 1;8(6):7002-8.
Product Image
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using CD217 mAb against human CD217 (AA: extra 33-320) recombinant protein. (Expected MW is 59.4 kDa)
Western Blot
Figure 3:Western blot analysis using CD217 mAb against HEK293 (1) and CD217 (AA: extra 33-320)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 4:Flow cytometric analysis of HL-60 cells using CD217 mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.