CD171 Primary Antibody
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31827ea_368.jpg?v=1666704638)
![Figure 2:Western blot analysis using CD171 mAb against human CD171 (AA: 20-197) recombinant protein. (Expected MW is 46.1 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31827rwb_369.jpg?v=1666704638)
![Figure 3:Western blot analysis using CD171 mAb against HEK293 (1) and CD171 (AA: 20-197)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31827twb_370.jpg?v=1666704638)
![Figure 4:Flow cytometric analysis of THP-1 cells using CD171 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31827fcm_371.jpg?v=1666704638)