CD162
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
2.Nat Microbiol. 2019 May;4(5):813-825.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32295ea.jpg?v=1669029526)
![Figure 2:Western blot analysis using CD162 mAb against human CD162 (AA: 42-320) recombinant protein. (Expected MW is 54.7 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32295rwb.jpg?v=1669029526)
![Figure 4:Immunohistochemical analysis of paraffin-embedded cerebellum tissues using CD162 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32295ihc-1.jpg?v=1669029526)
![Figure 5:Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using CD162 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32295ihc-2.jpg?v=1669029526)
![Figure 5:Flow cytometric analysis of THP-1 cells using CD162 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32295fcm.jpg?v=1669029963)